Electrospun manuka honey@PVP nanofibers enclosing chitosan-titanate for highly effective wound healing

Abstract The major challenge in skin tissue engineering is the creation of physically and functionally suitable extracellular matrix (ECM) scaffolds. A manuka honey-treated polyvinyl pyrrolidine (Mh@PVP) composite was successfully electrospun to produce nanofibrous scaffold that aids rapid growth ECM serves as a vehicle for drug delivery. Different characterizations namely SEM, XRD, FTIR were utilized elucidate fabricated scaffolds (ENS). By increasing concentration honey (Mh) formula, mechanical, tensile, conductivity properties (PVP) solutions significantly improved. As rose, width direction ENS produced altered. For wound healing, honey’s ability heal wounds faster may be boosted by higher PVP concentration, which makes more easily incorporated. Because its burst-and-continuous methylglyoxal release patterns, last up seven days, Mh an excellent choice helping body’s healing process. vivo assessment Mh@PVP nanocomposite nanofiber mat demonstrated substantial increase keratinocyte expression, reflecting great high regenerative healing. Most significantly, there no scarring associated with hair regrowth. This can mimic characteristics stimulate development. Graphical abstract